Martin De Kort;Meertinus Jan Smit;Constant Adriaan Anton Van Boeckel;Ebo Sijbren Bos
发明人:
Ebo Sijbren Bos,Martin De Kort,Meertinus Jan Smit,Constant Adriaan Anton Van Boeckel
申请号：
US11815131
公开号：
US08106007B2
申请日:
2006.01.31
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to conjugates of a polypeptide and an oligosaccharide, wherein the polypeptide is conjugated to at least one oligosaccharide-spacer residue, the oligosaccharide being a synthetic sulfated oligosaccharide comprising 4-18 monosaccharide units and per se having affinity to antithrombin III and the spacer being a bond or an essentially pharmacologically inactive flexible linking residue, or a pharmaceutically acceptable salt thereof. The conjugates of the invention have improved pharmacokinetic properties when compared to the original polypeptides (i.e. the corresponding non-conjugated polypeptides per se).
