EBO SIJBREN BOS,MARTIN DE KORT,MEERTINUS, JAN SMIT,CONSTANT ADRIAAN ANTON VAN BOECKEL
申请号：
MYPI 20060284
公开号：
MY148776A
申请日:
2006.01.23
申请国别(地区):
MY
年份:
2013
代理人:
摘要：
THE PRESENT INVENTION RELATES TO CONJUGATES OF A POLYPEPTIDE AND AN OLIGOSACCHARIDE, WHEREIN THE POLYPEPTIDE IS CONJUGATED TO AT LEAST ONE OLIGOSACCHARIDE-SPACER RESIDUE, THE OLIGOSACCHARIDE BEING A SYNTHETIC SULFATED OLIGOSACCHARIDE COMPRISING 4-18 MONOSACCHARIDE UNITS AND PER SE HAVING AFFINITY TO ANTITHROMBIN III AND THE SPACER BEING A BOND OR AN ESSENTIALLY PHARMACOLOGICALLY INACTIVE FLEXIBLE LINKING RESIDUE, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF. THE CONJUGATES OF THE INVENTION HAVE IMPROVED PHARMACOKINETIC PROPERTIES WHEN COMPARED TO THE ORIGINAL POLYPEPTIDES (I.E. THE CORRESPONDING NON-CONJUGATED POLYPEPTIDES PER SE).
