THANOU, Maria,WRIGHT, Michael James Lee,CENTELLES, Miguel,MILLER, Andrew David,GEDROYC, Wladyslaw
申请号：
GBGB2016/051693
公开号：
WO2016/198862A1
申请日:
2016.06.08
申请国别(地区):
GB
年份:
2016
代理人:
摘要：
The invention provides a (drug-containing) lipid nanoparticle with: (i) at least one phospholipid； (ii) at least one lysolipid； and (iii) at least one phospholipid comprising a hydrophilic polymer；and (iv) at least one structural lipid of formula (I) which has the following general structure: (I) wherein R and R' are long hydrocarbyl hydrophobic chains, Y is a linker element, and PHG is a polar head group described as large according to its van der Waals radius, and which is different from the phospholipid (i). The lipid nanoparticle can release a drug (or API) from within the lipid nanoparticleas a result of focussed ultrasound (FUS) applied continuously, at least twice, to a desired part of the body to induce hyperthermia (an increase in temperature). FUS is applied after the lipid nanoparticle containing the drug has been administered to the live subject, and causes controlled release of the drug at the desired site of the body. Ultrasound is then halted, and the site of interest allowed to cool. Ultrasound is then applied again. Lipidnanoparticles can be labelled (for MRI, NIRF imaging),enablin greal time monitoring of the drug in the human body. Imaging information can be used to direct and guide the nature of the FUS applied to the site of interest.L'invention concerne une nanoparticule lipidique (contenant un médicament) comportant : (i) au moins un phospholipide ； (ii) au moins un lysolipide ； et (iii) au moins un phospholipide comprenant un polymère hydrophile ； et (iv) au moins un lipide structural de formule (I) qui a la structure générale suivante : (I) où R et R' sont des chaînes hydrophobes d'hydrocarbures longues, Y est un élément de liant, et PHG est un groupe de tête polaire aussi grand que son rayon de van der Waals, et qui est différent du phospholipide (i). L'application d'ultrasons concentrés (FUS) de façon continue, au moins deux fois, sur une partie souhaitée du corps pour induire une hyperthermie (une augmentation de la température), a pour c
