Muthusamy Jayaraman;Kallanthottathil G. Rajeev;Laxman Eltepu;Steven Ansell;Jianxin Chen;Muthiah Manoharan
发明人:
Muthiah Manoharan,Muthusamy Jayaraman,Kallanthottathil G. Rajeev,Laxman Eltepu,Steven Ansell,Jianxin Chen
申请号：
US13128283
公开号：
US09186325B2
申请日:
2009.11.10
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention formula (I) provides lipids having the following structure XXXIII wherein: R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand； R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alky lhetro cycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand； and E is C(O)O or OC(O).
