Muthiah Manoharan,Muthusamy Jayaraman,Kallanthottathil G. Rajeev,Laxman Eltepu,Steven Ansell,Jianxin Chen
申请号：
US15617520
公开号：
US20180092971A1
申请日:
2017.06.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the inventionprovides lipids having the following structure XXXIII, wherein:R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand； R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand； and E is C(O)O or OC(O).
