RAGHAVAN, SUBHAREKHA,STELMACH, JOHN E.,SMITH, CAMERON J.,LI, HONG,WHITEHEAD, ALAN,WADDELL, SHERMAN T.,CHEN, YI-HENG,MIAO, SHOUWU,ORNOSKI, OLGA A.,GARFUNKLE, JOIE,LIAO, XIBIN,CHANG, JIANG,HAN, XIAOQING
申请号：
PE0022322012
公开号：
PE02222013A1
申请日:
2011.05.24
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to a compound of formula I, where a is a heteroaryl selected from (a), (b), among others * Indicates Union with the ring pirimidinilo and * * Indicates Union with the CH2 - R2 are independently h, RX and Ry, cycloalkyl alkyl C1 - C3 - 10, 6 r1 is H alkyl, Halo, C1 - 6, heterociclilo, heteroar ILO, among others R2 is alquenilo C2 C2 - 6 - 6, alquinilo, tcf3, (crd2)Among others R3 is t (crd2 cycloalkyl C3) - 10 (crd2) TCN, among other alkyl R4 is C1 - C3 - 10 6, cycloalkyl, Halo or Cf3 Rd is Halo, CF3 or alkyl C1 - 6 t is an integer from 0 to 4. Is the preferred Compound 4 - amino - 2 - Chloro - 5 - [(3 -) - trifluoropropil) - 1H - indazol - triazin-1-yl] - 5 - methyl - 4 - phenyl - 5.7 - dihydro - 5h pyrrolo [2,3-d] pyrimidine 6 - ona, among others. Also referred to a Pharmaceutical composition.Said Compound activates soluble guanylate cyclase, being useful for the treatment of hypertension, Heart Failure, diabetes, thrombosis, atherosclerosisSE REFIERE A UN COMPUESTO DE FORMULA I, DONDE: A ES UN HETEROARILO SELECCIONADO DE a), b), ENTRE OTROS * INDICA UNION CON EL ANILLO PIRIMIDINILO Y ** INDICA UNION CON EL CH2-R2 RX Y RY SON INDEPENDIENTEMENTE H, CICLOALQUILO C3-10, ALQUILO C1-6 R1 ES H, HALO, ALQUILO C1-6, HETEROCICLILO, HETEROARILO, ENTRE OTROS R2 ES ALQUENILO C2-6, ALQUINILO C2-6, (CRd2)tCF3, ENTRE OTROS R3 ES (CRd2)t CICLOALQUILO C3-10, (CRd2)tCN, ENTRE OTROS R4 ES ALQUILO C1-6, CICLOALQUILO C3-10, HALO O CF3 Rd ES HALO, CF3 O ALQUILO C1-6 t ES UN ENTERO ENTRE 0 A 4. ES COMPUESTO PREFERIDO 4-AMINO-2-[5-CLORO-3-(3,3,3-TRIFLUOROPROPIL)-1H-INDAZOL-1-IL]-5-METIL-5-FENIL-5,7-DIHIDRO-6H-PIRROLO[2,3-d]PIRIMIDIN-6-ONA, ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ACTIVA LA GUANILATO CICLASA SOLUBLE, SIENDO UTIL PARA EL TRATAMIENTO DE LA HIPERTENSION, FALLA CARDIACA, DIABETES, TROMBOSIS, ATEROSCLEROSIS
