BABAOGLU, KERIM,BACON, ELIZABETH M.,BJORNSON, KEYLA,GUO, HONGYAN,HALCOMB, RANDALL L.,HRVATIN, PAUL,LINK, JOHN O.,LIU, HONGTAO,MCFADDEN, RYAN,MITCHELL, MICHAEL L.,ROETHLE, PAUL A.,TAYLOR, JAMES,TRENKLE
申请号：
PE0026542012
公开号：
PE03852013A1
申请日:
2011.07.01
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to compounds derived from Naft acid - 2 - ilacetico of formula (i) wherein R1 is where A1A A1A or r1b is H, alkyl, Halo, (C1 - C6), among others is r1b (C1 - C6 alkyl (alkyl) - or - C1 - C6) - carbociclo (C3 - C7), aryl, among others R2 is 2a or R2B, where 2a is H, alkyl (C1 - C6) - o-alkyl (C1 - C6), between Other R2B is alkyl (C1 - C6), alquenilo (C2 - C6), haloalquilo (C1 - C6), among others R3 is R3A,Among others, where R3A is alkyl (C1 - C6), alquinilo (C2 - C6), or aril, among others R3 is R3A , among others, where R3A IS h R4 is R4A, among others, where R4A is aryl, heteroaryl or heterocycle R5 is r5a, between others, Where r5a is Halo, Nitro, CN, among others r6a R6, among others, where r6a e S H, Halo, alkyl (C1 - C6), among others R7 is R7a, among others, where H is alquenilo R7a (C2, C6)Cycloalkyl (C3 - C7), among others R8 is r8a, among others, where r8a is Halo, Nitro, CN, among others. Preferred compounds are: acid (S) - 2 - (tert Butoxy - 2 - 1 - (4-chlorophenyl) - 3 - (2 - dimetilaminometil) naftalen - il) acetic acid (S) - 2 - (tert Butoxy - 2 - 1 - (4-chlorophenyl) - 3 - ((iloxi pyridin - 3 - Methyl - 2 -)) naftalen il) acetic acid among others. It also relates to a Pharmaceutical composition.These compounds are useful in the treatment of AIDSSE REFIERE A COMPUESTOS DERIVADOS DE ACIDO NAFT-2-ILACETICO DE FORMULA (I) DONDE R1 ES R1a O R1b, DONDE R1a ES H, HALO, ALQUILO(C1-C6), ENTRE OTROS R1b ES ALQUIL(C1-C6)-O-ALQUIL(C1-C6)-CARBOCICLO(C3-C7), ARILO, ENTRE OTROS R2 ES R2a O R2b, DONDE R2a ES H, ALQUILO(C1-C6), -O-ALQUILO(C1-C6), ENTRE OTROS R2b ES ALQUILO(C1-C6), ALQUENILO(C2-C6), HALOALQUILO(C1-C6), ENTRE OTROS R3 ES R3a, ENTRE OTROS, DONDE R3a ES ALQUILO(C1-C6), ALQUINILO(C2-C6), -O-ARILO, ENTRE OTROS R3 ES R3a, ENTRE OTROS, DONDE R3a ES H R4 ES R4a, ENTRE OTROS, DONDE R4a ES ARILO, HETEROCICLO O HETEROARILO R5 ES R5a, ENTRE OTROS, DONDE R5a ES HALO, NITRO, CN, ENTRE OTROS R6 ES R6a, ENTRE OTROS, DONDE R6a ES H, HALO, ALQUILO(C1-C6), ENTRE
