MODIFICATIONS ET UTILISATIONS DE PEPTIDES DE CONOTOXINE

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专利权人:

LLC;KINETA CHRONIC PAIN

发明人:

IADONATO, SHAWN P.,MUNOZ, ERNESTO J.

申请号：

CA2966865

公开号：

CA2966865A1

申请日:

2015.11.06

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The present disclosure describes analog conotoxin peptides of the a-conotoxin peptide RgIA. These analog conotoxin peptides block the a9a10 subtype of the nicotinic acetylcholine receptor (nAChR) and can be used for treating pain and inflammation including inflammatory pain, cancer related pain, and neuropathic pain. The RgIA analogs described in the present invention include a variety of sequence modifications and chemical modifications that are introduced to improve the drug-like characteristics of RgIA analogs and thereby increase their therapeutic value.

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