Pyrazine carboxamides semblable à l'Amiloride en tant que bloqueurs d'ENaC

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专利权人:

NOVARTIS AG

发明人:

申请号：

EP08860731.2

公开号：

EP2231280B1

申请日:

2008.12.09

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

A compound of Formula I in free or salt or solvate form, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

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