In a dynamic contrast temperature system includinga thermocycling block and an organism zone multi-modules temperatureapplicator, a method of spatiotemporal temperature-physiological optimizingincludes modules structure arranging and modulating a module temperatureaction with a law, a range and a frequency providing a cooling phase anda heating phase of a "drop-shaped" form law so, that each two side by sidedisposed the modules form a temperature pair with a modulated binarytemperature action gradient, and a modulation comparative phase providesa phase shift to a comparative phase of an independent periodic additionalaction process； and gradient-wave therapeutically optimized changing themodulation parameters in dependence on the changes of the organismphysiological characteristics
