In a dynamic contrast temperature system including a thermocycling block and an organism zone multi-modules temperature applicator a method of spatiotemporal temperature-physiological optimizing includes modules structure arranging and modulating a module temperature action with a law, a range and a frequency providing a cooling phase and a heating phase of a “drop-shaped” form law so, that each two side by side disposed the modules form a temperature pair with a modulated binary temperature action gradient, and a modulation comparative phase provides a phase shift to a comparative phase of an independent periodic additional action process； and gradient-wave therapeutically optimized changing the modulation parameters in dependence on the changes of the organism physiological characteristics.
