MACDONALD, LYNN,MURPHY, ANDREW J.,GURER, CAGAN,MCWHIRTER, JOHN,VORONINA, VERA,HARRIS, FAITH,STEVENS, SEAN
申请号：
CA3074400
公开号：
CA3074400A1
申请日:
2012.10.26
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention provides genetically modified non-human animals that expresschimerichuman/non-human MHC I polypeptide and/or human or humanized beta2microglobulinpolypeptide, as well as non-human embryos, cells, and tissues comprising thesame. Also providedare constructs for making said genetically modified animals and methods ofmaking the same.Methods of using the genetically modified animals to study various aspects ofhuman immunesystem are provided.
