MACDONALD, LYNN,MURPHY, ANDREW J.,GURER, CAGAN,MCWHIRTER, JOHN,VORONINA, VERA,HARRIS, FAITH,STEVENS, SEAN
申请号：
CA2850387
公开号：
CA2850387A1
申请日:
2012.10.26
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized beta2 microglobulin polypeptide, as well as non-human embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
