Lynn MACDONALD,Andrew J. MURPHY,Vera VORONINA,Cagan GURER
申请号：
US14185316
公开号：
US20140245467A1
申请日:
2014.02.20
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I and MHC II polypeptides and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
