This invention obesity and the high fat blood symptom, offers the new thiazole derivative and the intermediate field and these synthetic methods of being displayed with the chemical compound which possesses activity in the peroxisome multiplication child activated receptor which can be used for the remedy of arteriosclerosis and diabetes.本発明は肥満、高脂血症、動脈硬化及び糖尿病の治療に使用できるペルオキシソーム増殖子活性化受容体δに活性を有する化合物で表される新規チアゾール誘導体と中間体及びこれらの合成方法を提供する。