DODGE James,DODGE James,SHIHABUDDIN Lamya,SHIHABUDDIN Lamya,ORIORDAN Catherine R.,ORIORDAN Catherine R.
申请号：
SI200731840
公开号：
SI2029742T1
申请日:
2007.06.07
申请国别(地区):
SI
年份:
2016
代理人:
摘要：
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subjects spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subjects spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the subjects brain.
