Gene therapy for amyotrophic lateral sclerosis and other spinal cord disorders

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专利权人:

ジェンザイム・コーポレーション

发明人:

ジェイムズ・ドッジ,ラムヤ・シハブッディン,キャサリン・アール・オリオーダン

申请号：

JP2016219801

公开号：

JP6320489B2

申请日:

2016.11.10

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/