James DODGE,Lamya SHIHABUDDIN,Catherine O'RIORDAN,Catherine ORIORDAN
申请号：
US14692469
公开号：
US20160067312A1
申请日:
2015.04.21
申请国别(地区):
US
年份:
2016
代理人:
摘要：
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain.
