Gregory Stephanopoulos,Christian M. Metallo,Joanne K. Kelleher,Othon Iliopoulos,Paulo Alexandre da Costa Gameiro Guerreiro
申请号：
US13809333
公开号：
US10064885B2
申请日:
2011.07.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A novel pathway in cancer cell metabolism is identified. Targeting of any gene, protein, or enzyme that modulates activity or flux through this pathway, including, but not limited to IDH1, isocitrate dehydrogenase 2 (IDH2), aconitase 1 (ACO1), aconitase 2 (ACO2), glutaminase (GLS), glutamate dehydrogenase (GDH) and transaminase, provides effective means of inhibiting tumor growth.
