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Ring-fused compound
专利权人:
LTD.;SATO PHARMACEUTICAL CO.
发明人:
Keita Nagai,Koh Nagasawa,Hirobumi Takahashi,Motoaki Baba,Shinichi Fujioka,Eri Kondoh,Kenichi Tanaka,Yoshiki Itoh
申请号:
US14619980
公开号:
US09359350B2
申请日:
2015.02.11
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention relates to a compound that has URAT1 inhibitory action, and a URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition comprising the compound. More specifically, the present invention relates to a compound represented by Formula (I) below.[in the formula,R1 is -Q1-A1 and the like; is a double bond or a single bond; when is a double bond, W1 is a nitrogen atom or a group represented by the general formula: ═C(Ra)—, and W2 is a nitrogen atom or a group represented by the general formula: ═C(Rb)—; when is a single bond, W1 is a group represented by the general formula: —C(Raa)(Rab)— or a group represented by the general formula: —(C═O)—, and W2 is a group represented by the general formula: —C(Rba)(Rbb)—, a group represented by the general formula: —(C═O)— or a group represented by the general formula: —N(Rbc)—; W3, W4 and W5 are each independently a nitrogen atom or a methine group and the like that may have a substituent; X is a single bond, an oxygen atom and the like; Y is a single bond or (CRYiRYi′)n; and Z is a hydroxyl group or COOR2 and the like.
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