This invention relates to a composition for suppressing activity of helicobacter pylori, which contains an effective dose of ovatodiolide or derivatives thereof for suppressing the growth of helicobacter pylori and an acceptable carrier. This invention also provides a usage of ovatodiolide for producing a composition for killing helicobacter pylori. This invention further provides a usage of ovatodiolide for producing a medicine for curing gastric ulcer. Ovatodiolide separated from extracts of natural substances is proven to have the efficacy of suppressing the growth of helicobacter pylori or killing helicobacter pylori, and can be used in various industrial usages for suppressing or killing helicobacter pylori, with the advantages of no side effect, easy fabrication and preparation and low fabrication cost.本發明係提供一種具有抗幽門螺旋桿菌(Helicobacter pylori)活性的組成物，其含有有效抑制螺旋桿菌生長劑量的魚針草內酯(ovatodiolide)或其衍生物以及其可接受的載劑。本發明亦提供一種魚針草內酯於製造供用於殺除幽門螺旋桿菌之組成物的用途。本發明亦提供一種魚針草內酯於製造供用於治療胃潰瘍之醫藥品的用途。由天然材料萃取物所分離的魚針草內酯經證實具有抑制幽門螺旋桿菌生長或殺除幽門螺旋桿菌之功效，可供用於各種不同產業應用於抑制或插除幽門螺旋桿菌相關的用途，具有無副作用、容易製備以及低製造成本等優點。
