HUNZIKER DANIEL,HERT JR´ME,KUEHNE HOLGER,MATTEI PATRIZIO,RUDOLPH MARKUS
申请号：
IN201617031337
公开号：
IN201617031337A
申请日:
2016.09.14
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The invention provides novel compounds having the general formula (I) wherein R R A and A are as described herein compositions including the compounds. These compounds of formula (I) are useful for therapy or prophylaxis in a mammal and in particular to autotaxin (ATX) inhibitors which are inhibitors of lysophosphatidic acid (LPA) production and thus modulators of LPA levels and associated signaling for the treatment or prophylaxis of renal conditions liver conditions inflammatory conditions conditions of the nervous system conditions of the respiratory system vascular and cardiovascular conditions fibrotic diseases cancer ocular conditions metabolic conditions cholestatic and other forms of chronic pruritus and acute and chronic organ transplant rejection.
