di Giorgio, Patrick,Hert, Jerome,Hunziker, Daniel,Kuehne, Holger,Mattei, Patrizio,Rudolph, Markus
申请号:
UAA201610689
公开号:
UA118582C2
申请日:
2015.03.23
申请国别(地区):
UA
年份:
2019
代理人:
摘要:
The invention provides novel compounds having the general formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds. The compounds of formula (I) are useful as autotaxin (ATX) inhibitors which are inhibitors of lysophosphatidic acid (LPA) production and thus modulators of LPA levels and associated signaling; in particular they are useful for the treatment or prophylaxis of renal conditions, liver conditions, inflammatory conditions, conditions of the nervous system, conditions of the respiratory system, vascular and cardiovascular conditions, fibrotic diseases, cancer, ocular conditions, metabolic conditions, cholestatic and other forms of chronic pruritus and acute and chronic organ transplant rejection.В даному винаході запропоновані нові сполуки, які мають загальну формулу (І) , (I) де R1, R2, A, W, m, n, р і q є такими, як тут описано, композиції, які включають зазначені сполуки, і способи застосування зазначених сполук.