PROCESS FOR PREPARING METHYL {4,6-DIAMINO-2-[1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YL]PYRIMIDIN-5-YL}CARBAMATE AND ITS PURIFICATION FOR USE AS PHARMACEUTICALLY ACTIVE COMPOUND

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专利权人:

BAYER SCHERING PHARMA AKTIENGESELLSCHAFT

发明人:

MAIS, FRANZ-JOSEF,梅斯 弗朗茨约瑟夫,梅斯 弗朗茨約瑟夫,REHSE, JOACHIM,瑞斯 约阿希姆,瑞斯 約阿希姆,JOENTGEN, WINFRIED,乔根 韦佛瑞德,喬根 韋佛瑞德,SIEGEL, KONRAD,西格尔 康诺,西格爾 康諾

申请号：

TW099140891

公开号：

TW201200513A

申请日:

2010.11.26

申请国别(地区):

TW

年份:

2012

代理人:

摘要：

The present invention relates to processss for preparing methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate, i.e. the compound of the formula (I)and to a process for purifying the crude product of the formula (I) for use as pharmaceutically active compound, where, for purification, methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl} carbamate sulphinyldimethane (1:2) of the formula (II) is isolated as intermediate or is generated as intermediate in this purification process, if appropriate present in a mixture.本發明係關於用於製備{4,6-二胺基-2-[1-(2-氟苯甲基)-1H-吡唑並[3,4-b]吡啶-3-基]嘧啶-5-基}胺基甲酸甲酯(即式(I)化合物)之方法以及用於純化式(I)之粗產物作為醫藥活性化合物使用之方法,在純化時,式(II)之{4,6-二胺基-2-[1-(2-氟苯甲基)-1H-吡唑並[3,4-b]吡啶-3-基]嘧啶-5-基}胺基甲酸甲酯亞磺醯基二甲烷(1:2)在此純化方法中是以中間物分離或以中間物產生,如果適當時,以混合物存在。

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