PROCESS FOR PREPARING IMATINIB OR SALT THEREOF and PHARMACEUTICAL COMPOSITION

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专利权人:

CHEMAGIS LTD

发明人:

LIU XING,HE XUNGUI,YUAN WANG,MICHEL BEKHAZI,SONIA KRIVONOS,EDNA DANON

申请号：

BRPI0809890

公开号：

BRPI0809890A2

申请日:

2008.05.01

申请国别(地区):

BR

年份:

2014

代理人:

摘要：

Provided is a process for producing imatinib and salts thereof, e.g., imatinib mesylate. The process includes reacting 4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid with N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine in the presence of a carboxylic acid coupling reagent, to produce imatinib, and optionally converting the imatinib into a salt.

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中国工程科技知识中心

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http://www.ckcest.cn/home/