Enrico Di Cera;Leslie Pelc;Nicola Pozzi;Prafull Gandhi;David Collier Wood;Andras Gruber
发明人:
Enrico Di Cera,Andras Gruber,Prafull Gandhi,Leslie Pelc,Nicola Pozzi,David Collier Wood
申请号：
US13331109
公开号：
US20120164129A1
申请日:
2011.12.20
申请国别(地区):
US
年份:
2012
代理人:
摘要：
One aspect of the invention contemplates a mutant E-WE thrombin precursor that contains the SEQ ID NO:1 amino acid residue sequence. Another aspect contemplates a thrombin precursor that contains the amino acid residue sequence Asp/Glu-Gly-Arg at positions 325, 326 and 327 based on the preprothrombin sequence. A third aspect contemplates a thrombin precursor that contains the SEQ ID NO:1 amino acid residue sequence as well as the amino acid residue sequence Asp/Glu Gly Arg at positions 325, 326 and 327 based on the preprothrombin sequence. Also contemplated is a composition that contains an effective amount of mutant thrombin dissolved or dispersed in a pharmaceutically acceptable carrier. A method is also disclosed for enhancing treating and preventing thrombosis in a mammal in need using that composition.
