Postopki in sestavki za dostavo iduronat-2-sulfataze v centralni živčni sistem

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专利权人:

Shire Human Genetic Therapies; Inc.

发明人:

ZHU Gaozhong,LOWE Kris,SHAHROKH Zahra,CHRISTIAN James,FAHRNER Rick,PAN Jing,WRIGHT Teresa Leah,CALIAS Pericles

申请号：

SI201131775

公开号：

SI2593131T1

申请日:

2011.06.25

申请国别(地区):

SI

年份:

2019

代理人:

摘要：

The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/