Disclosed are an ophthalmic micro-stud formulation, a process for preparing the same and a method for treating and preventing oculopathy with the same. The ophthalmic micro-stud formulation comprises a drug-loading part as a head of the micro-stud, a lubrication part as a bottom of the micro-stud, and a soluble carrier material, wherein the lubrication part is attached to the soluble carrier material.