KOSKELAINEN, Tuula,LINNANEN, Tero,MINKKILÄ, Anna,MÄKELÄ, Mikko,POHJAKALLIO, Antti
申请号：
ES13719297
公开号：
ES2674945T3
申请日:
2013.03.28
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound that is of Formula I, ** Formula ** in which X is O or S； R1 is hydroxy, halogen, (C1-C6) alkyl, halo (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C3-C6) cycloalkyl, (C1-C6) alkoxy, haloalkoxy ( C1-C6), hydroxyalkyl (C1-C6), cyano, (R6) 2N- (C>； = O) -, alkyl (C1-C6) -S-, or a heteroaryl group which is an aromatic monocyclic ring system of 3 7-member, containing one to three heteroatoms selected from oxygen, nitrogen and sulfur, whose heteroaryl may be unsubstituted or substituted with 1 or 2 substituents each independently being hydroxy, halogen, oxo, (C1-C4) alkyl, alkoxy (C1-C4), or haloalkyl (C1-C4)； R2 is H or (C1-C6) alkyl； R3 is H, (C1-C6) alkyl, halo (C1-C6) alkyl, or (C1-C6) alkoxy-(C1-C6) alkyl； R4 is H or (C1-C2) alkyl； R5 is H, hydroxy, halogen, (C1-C6) alkyl, or (C1-C6) alkoxy； R6 is H； or R1 and R2 form, together with the carbon atoms in the ring to which they are attached, a saturated or unsaturated 6 or 7 membered carbocyclic ring, wherein said carbocyclic ring is unsubstituted or substituted with 1 or 2 substituents , each independently being hydroxy, oxo, halogen, (C1-C2) alkyl, (C1-C2) alkoxy, hydroxy (C1-C2) alkyl, or halo (C1-C2) alkyl； or is a pharmaceutically acceptable salt thereof.Un compuesto que es de Fórmula I,**Fórmula** en la que X es O o S ； R1 es hidroxi, halógeno, alquilo (C1-C6), haloalquilo (C1-C6), alquenilo (C2-C6), alquinilo (C2-C6), cicloalquilo (C3- C6), alcoxi (C1-C6), haloalcoxi (C1-C6), hidroxialquilo (C1-C6), ciano, (R6)2N-(C>；=O)-, alquil (C1-C6)-S-, o un grupo heteroarilo que es un sistema anular monocíclico aromático de 3 a 7 miembros, que contiene de uno a tres heteroátomos seleccionados de oxígeno, nitrógeno y azufre, cuyo heteroarilo puede estar sin sustituir o sustituido con 1 o 2 sustituyentes siendo cada uno independientemente hidroxi, halógeno, oxo, alquilo (C1-C4), alcoxi (C1- C4), o haloalquilo (C1-C4)； R2 es H o alquilo (C1-C6)； R3 es H, alquilo (C1-C6), haloalquilo (C1-C6), o alcoxi (C1-C6
