Mikael Trollsas,John Stankus,James Su,Syed Hossainy,Joshua Takeshi Smith,Shadid Askar
申请号：
US15242403
公开号：
US20170042816A1
申请日:
2016.08.19
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an initial release, a triphasic release, and release over thirty to ninety days of the biologic therapeutic. In some embodiments, the formulations exhibit reversible precipitation of the biologic therapeutic into precipitates having a diameter of about 50 nm to about 10 μm.
