An exemplary insulin infusion set that further provides one or more setelements including the hub, hub adhesive,fluid line tubeset, connectors, catheters and insertion needles which can beimpregnated with, coated with, or otherwise configuredto contain and administer an anesthetic at the insertion and set placementlocations to minimize user discomfort and the risk ofcomplications associated with the use of infusion sets. To do so, the systemand method provides steps for mixing at a step (22) atleast two of a solvent, an anesthetic, and a lubricant, applying the mixedcompound as a coating to at least one surface of the infusionset, patch pump, or an element thereof at a step (24), and then substantiallyremoving the solvent after coating at a step (26)to provide at least one of an anesthetic layer and a lubricant layer upon theinfusion set, patch pump, or an element thereof.
