INC.;SHIRE HUMAN GENETIC THERAPIES;SHIRE HUMAN GENETIC THERAPIES, INC.;FONDAZIONE TELETHON
发明人:
MEIYAPPAN, MUTHURAMAN,DEMATTEIS, MARIA A.
申请号：
CA2955297
公开号：
CA2955297A1
申请日:
2015.07.23
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
In some embodiments, the present invention provides method of identifying compounds that bind to phosphoinositol 4-phosphate adaptor protein-2 (FAPP2), including the steps of computationally identifying a compound that binds to FAPP2 using the atomic coordinates of at least the amino acids which make up the substrate binding pocket of FAPP2. Also provided are methods of designing, selecting and/or optimizing a compound that binds to FAPP2.
