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STABLE GRANULAR PHARMACEUTICAL COMPOSITION OF SOLIFENACIN OR ITS SALT
专利权人:
发明人:
申请号:
EP05820232.6
公开号:
EP1832288B1
申请日:
2005.12.26
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention relates to the provision of a stable particulate pharmaceutical composition of solifenacin or a salt thereof, which is in a spherical shape suitable for coating and in which degradation with time can be inhibited when a pharmaceutical preparation of solifenacin or a salt thereof is supplied to clinical fields. More particularly, it relates to a particulate pharmaceutical composition that can be obtained by using a binder having a Tg or mp lower than 174°C upon formulating a particulate composition of solifenacin into a pharmaceutical preparation. Further, by performing a crystallization-promoting treatment after the particulate pharmaceutical composition is produced, a more stable particulate composition of solifenacin or a salt thereof can be provided.
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