abstractgranular pharmaceutical composition the present invention relates to a granular pharmaceutical composition obtained by coating a nucleus with: (1) a layer containing a material having a damp-proofing function, and (2) a drug layer containing linaclotide, a pharmaceutically acceptable salt, or a hydrate thereof, and (3) a layer containing a material having a damp-proofing function. also, the present invention relates to a method for manufacturing the granular pharmaceutical composition obtained by coating the nucleus with (1) the layer containing the material having a damp-proofing function, (2) the drug layer containing the linaclotide, the pharmaceutically acceptable salt , or the hydrate thereof, and (3) the layer containing the material having a damp-proofing function. _____________________________________________________________________________ abstract translated below: abstract patent: "granular pharmaceutical composition". The present invention relates to a granular pharmaceutical composition obtained by coating a core with: (1) a layer containing a material having a waterproofing function and (2) a linaclotide-containing drug layer, a pharmaceutically acceptable salt, or a hydrate. of this (3) a layer containing a material with a waterproofing function. furthermore, the present invention relates to a method for manufacturing the granular pharmaceutical composition obtained by coating the core with (1) the material-containing layer having a waterproofing function, (2) the linaclotide-containing drug layer, the pharmaceutically acceptable salt or hydrate thereof and (3) the layer containing the material with a waterproofing function.abstractgranular pharmaceutical composition the present invention relates to a granular pharmaceutical composition obtained by coating a nucleus with: (1) a layer containing a material having a damp-proofing function, and (2) a drug layer containing linaclotide, a pharmaceutically acceptable salt, or a hydrate thereof, and
