CHRISTINE HIEMSTRA,JOHAN ZUIDEMA,ROB STEENDAM,THEODORUS ADRIANUS CORNELIUS FLIPSEN
申请号：
BR112014001441
公开号：
BR112014001441A2
申请日:
2012.07.23
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
This invention is directed to a biodegradable, semi-crystalline, phase separated thermoplastic multi-block copolymer, a process for preparing said multi-block copolymer, a composition for the delivery of at least one biological active compound, and to a method for delivering a biologically active compound to a subject in need thereof. A multi-block copolymer of the invention is characterised in that: a) it comprises at least one hydrolysable pre-polymer (A) segment and at least one hydrolysable pre-polymer (B) segment, b) said multi-block copolymer having a Tg of 37° C. or less and a Tm of 110-250° C. under physiological conditions； c) the segments are linked by a multifunctional chain-extender； d) the segments are randomly distributed over the polymer chain； e) at least part of the pre-polymer (A) segment is derived from a water-soluble polymer.
