Johan Zuidema;Theodorus Adrianus Cornelius Flipsen;Rob Steendam;Christine Hiemstra
发明人:
Rob Steendam,Theodorus Adrianus Cornelius Flipsen,Christine Hiemstra,Johan Zuidema
申请号：
US14233961
公开号：
US20140199385A1
申请日:
2012.07.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
This invention is directed to a biodegradable, semi-crystalline, phase separated thermoplastic multi-block copolymer, a process for preparing said multi-block copolymer, a composition for the delivery of at least one biological active compound, and to a method for delivering a biologically active compound to a subject in need thereof.A multi-block copolymer of the invention is characterised in that:a) it comprises at least one hydrolysable pre-polymer (A) segment and at least one hydrolysable pre-polymer (B) segment,b) said multi-block copolymer having a Tg of 37° C. or less and a Tm of 110-250° C. under physiological conditions；c) the segments are linked by a multifunctional chain-extender；d) the segments are randomly distributed over the polymer chain；e) at least part of the pre-polymer (A) segment is derived from a water-soluble polymer.
