STEENDAM ROB,FLIPSEN THEODORUS ADRIANUS CORNELIUS,HIEMSTRA CHRISTINE,ZUIDEMA JOHAN
申请号：
NZ62039212
公开号：
NZ620392A
申请日:
2012.07.23
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The disclosure is directed to a biodegradable, semi-crystalline, phase separated thermoplastic multi-block copolymer, a process for preparing said multi-block copolymer, a composition for the delivery of at least one biological active compound, and to o a method for delivering a biologically active compound to a subject in need thereof. A multi-block copolymer of the invention is characterised in that: a) it comprises at least one hydrolysable pre-polymer (A) segment and at least one hydrolysable pre-polymer (B) segment, b) said multi-block copolymer having a T of 37 °C or less and a Tm of 110-250 °C under physiological conditions c) the segments are linked by a multifunctional chain-extender d) the segments are randomly distributed over the polymer chain e) at least part of the pre-polymer (A) segment is derived from a water-soluble polymer.
