The invention discloses liposome production technologies, provide a sodium rice grade liposomal particle size and high water soluble drug packing rate. Specifically disclose production W1/O/W2, its feature of emulsion includes: that the organic solvent (zero) of (1) emulsifier is volatile organic solvent, aqueous solvent (W1) and mixed lipids ingredient (F1) prepare (1) generated in W1/O lotions and (2) W1/O emulsion dispersion steps and use porous film preparation W1/O/W2 lotions at aqueous solvent (W2), it is treatment and hydrophilic component that wherein porous film surface, which has, so that the water contact angle on the surface includes the air in 0 to 42 °
