Hamid Hoveyda,Graeme Fraser,Kamel Benakli,Eric Marsault,Mark L. Peterson
申请号：
US15178303
公开号：
US20170042858A1
申请日:
2016.06.09
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides novel conformationally-defined macrocyclic compounds that can function as selective modulators of the ghrelin receptor (growth hormone sceretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, bone disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.
