An oligonucleotide inhibitor of tyrosinase gene expression comprising a sequence of 15-25 nucleotides including a specific 21 nucleotide sequence (SEQ ID NO:1) which hybridizes to the human tyrosinase gene by Hoogsteen pairing to form a triple helix structure, is new. An oligonucleotide inhibitor of tyrosinase gene expression comprising a sequence of 15-25 nucleotides including a specific 21 nucleotide sequence (SEQ ID NO:1) which hybridizes to the human tyrosinase gene by Hoogsteen pairing to form a triple helix structure, is new. Independent claims are included for: (1) a cosmetic or dermatological composition comprising the oligonucleotide inhibitor； and (2) cosmetic process of treatment for depigmentation or to bleach the skin or hair, comprising application of the composition on pigmented zone of the skin or pilous of hair and optional repetition of the operation until the appearance of depigmented effect. 5'-C*TTC*TC*TC*TTTTTC*C*TTTTTC*-3' sequence (SEQ ID No. 1), where C* is a 5-methyl-cytosine ACTIVITY : Dermatological. MECHANISM OF ACTION : Tyrosinase expression inhibitor. The ability of the oligonucleotide to inhibit the expression of human tyrosinase was tested using reverse transcriptase polymerase chain reaction. The results showed that the LNA oligonucleotide exhibited an inhibition of 49%.본 발명은 상보적인 염기들 사이에 후그스틴 페어링을 통하여 인간 타이로시네이즈를 코딩하는 유전자와 특이적으로 교잡하는 앤티(anti)-진(gene) 올리고뉴크레오타이드에 관한 것으로, 상기 올리고뉴크레오타이드는 인간 타이로시네이즈 유전자와 삼중 나선 구조를 형성한다. 본 발명은 또 화장료 또는 피부과적 조성물에서 탈색 또는 피부 미백제로 상기 올리고뉴크레오타이드의 용도에 관한 것이다.
