PROBLEM TO BE SOLVED: To provide a hair-growth promoting agent by promoting the expression of VEGF and FGF7 genes, an agent for promoting the regeneration of periodontal tissue, and a pharmaceutical agent effective to treat or prevent peripheral arterial disease.SOLUTION: According to the present invention, there are provided a hair-growth promoting agent by promoting the expression of VEGF and FGF7 genes using an Ishige okamurae extract as an effective ingredient. There are also provided an agent for promoting the regeneration of periodontal tissue and a pharmaceutical agent effective to treat or prevent peripheral arterial disease.SELECTED DRAWING: Figure 1【課題】 ＶＥＧＦ及びＦＧＦ７遺伝子の発現を促進し、発毛促進剤を得ること、さらには歯周組織再生促進剤や末梢動脈疾患の治療又は予防に有効な製剤を得ることを目的とする。【解決手段】 イシゲ（Ishige okamurae）の抽出物を有効成分とすることによって、ＶＥＧＦ及びＦＧＦ７遺伝子の発現を促進し、発毛促進剤を得ること、さらには歯周組織再生促進剤や末梢動脈疾患の治療又は予防に有効な製剤を得ることができた。【選択図】図１
