The present invention provides anti-CD39 antibodies or antigen-binding fragments thereof, isolated polynucleotides encoding the aforementioned antibodies or antigen-binding fragments thereof, pharmaceutical compositions comprising the aforementioned antibodies or antigen-binding fragments thereof, and uses thereof.本發明提供了抗CD39抗體或其抗原結合片段、編碼上述抗體或其抗原結合片段之分離的多核苷酸、包括上述抗體或其抗原結合片段之醫藥組合物及其用途。