Laurence E. Burgess,Mark Laurence Boys,Robert D. Groneberg,Darren M. Harvey,Timothy Kercher,Christopher F. Kraser,Ellen Laird,Eugene Tarlton,Qian Zhao,Lily Huang
申请号:
US13640099
公开号:
US08962596B2
申请日:
2011.04.11
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Compounds of Formula I:and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, R7, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.