The present invention relates to a slow release solid oral nutraceutical and/or pharmaceutical composition comprising: c) a core containing a donor of methyl groups and at least one pharmaceutically acceptable excipient and d) an outer coating containing shellac and/or a pharmaceutically acceptable salt thereof magnesium stearate and at least one pharmaceutically acceptable excipient. The coating of said solid oral composition allows the donor of methyl groups preferably SAMe and/or a pharmaceutically acceptable salt thereof to cross intact the gastric barrier and release the same in a continuous and complete manner along the entire digestive tract.
