RUSLI ISMAIL,MOHAMED ASHRAF ALI,TAN SOO CHOON,YEONG KENG YOON,ANG CHEE WEI,RAJU SURESH KUMAR,HASNAH OSMAN
申请号：
MYPI 2011000319
公开号：
MY153034A
申请日:
2011.01.21
申请国别(地区):
MY
年份:
2014
代理人:
摘要：
ACCORDINGLY, THE INVENTION DISCLOSES COMPOUNDS OF PYRROLOTHIAZOLE MOIETY CONTAINING WITH MONO BIS SUBSTITUTED CURCUMIN MOLECULES WHICH IMPROVES SOLUBILITY OF CURCUMIN. THE INVENTION ALSO DISCLOSES THE METHOD IN SYNTHESIZING THESE COMPOUNDS WHEREIN THE STEPS INCLUDES MIXING CURCUMIN, ISATIN DERIVATIVES OR NINHYDRIN AND THIOPROLINE (THIAZOLIDINE-4-CARBOXYLIC ACID) IN 20 ML METHANOL. THE MIXTURE WAS THEN REFLUXED WITH A SOLVENT ON A WATER BATH AND EXCESS SOLVENT WAS REMOVED UNDER VACUUM. THE RESIDUE SUBJECTED TO FLASH COLUMN CHROMATOGRAPHY USING PETROLEUM ETHER: ETHYL ACETATE MIXTURE (4:1) AS ELUENT TO AFFORD THE PRODUCT. THE RATIO FOR CURCUMIN: ISATIN DERIVATIVE/NINHYDRIN: THIOPROLINE (THIAZOLIDINE-4-CARBOXYLIC ACID) IS 1:1:2 AND 1:2:4.
