LI, ZHEN,LI, XIAOKAI,BUSH, ERIK W.,ZHU, RUI,SHU, DONGXU,BENSON, JONATHAN,SHAO, PATRICK,FOWLER-WATTERS, MATTHEW
申请号：
CA3079402
公开号：
CA3079402A1
申请日:
2018.10.31
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Synthetic a?ß6 integrin ligands of Formula I having serum stability and affinity for integrin a?ß6, which is a receptor expressed in a variety of cell types, are described. The described ligands are usful for delivering cargo molecules, such as RNAi agents or other oligonucleotide- based compounds, to cells that express integrin a?ß6, and thereby facilitating the uptake of the cargo molecules into these cells. Compositions that include a?ß6 integrin ligands and methods of use are also described.
