LI, Zhen,LI, Xiaokai,BUSH, Erik W.,ZHU, Rui,SHU, Dongxu,BENSON, Jonathan,SHAO, Patrick,FOWLER-WATTERS, Matthew
申请号：
AU2018359515
公开号：
AU2018359515A1
申请日:
2018.10.31
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
Synthetic ανβ6 integrin ligands of Formula I having serum stability and affinity for integrin ανβ6, which is a receptor expressed in a variety of cell types, are described. The described ligands are usful for delivering cargo molecules, such as RNAi agents or other oligonucleotide- based compounds, to cells that express integrin ανβ6, and thereby facilitating the uptake of the cargo molecules into these cells. Compositions that include ανβ6 integrin ligands and methods of use are also described.
