Srinivasa R. Karra;Xuliang Jiang;Andreas Goutopoulos;Henry Yu;Lizbeth Celeste De Selm;Benny C. Askew, Jr.
发明人:
Henry Yu,Lizbeth Celeste De Selm,Xuliang Jiang,Benny C. Askew, Jr.,Srinivasa R. Karra,Andreas Goutopoulos
申请号:
US13062413
公开号:
US08815872B2
申请日:
2009.09.03
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Macrocyclic derivative compounds that inhibit protein kinase enzymes are disclosed along with pharmaceutical compositions comprising these compounds and methods for synthesizing the same. Such compounds have utility in the treatment of proliferative diseases resulting from unregulated and/or disturbed kinase activity such as cancers, psoriasis, viral and bacterial infections, inflammatory and autoimmune diseases.