The present invention relates to selective inhibitors of PI3K delta protein kinases, methods of preparing them, pharmaceutical compositions containing them and methods of treatment and/or prevention of kinase mediated diseases or disorders with them.本發明係關於PI3Kδ蛋白激酶之選擇性抑制劑、其製備方法、含有其之醫藥組合物及用其治療及/或預防激酶介導的疾病或病症之方法。