Provided herein are 3,5-diaminopyrazoles, for example, compounds of Formula LA, that are useful for modulating regulated-in-COPD kinase activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a RC kinase-mediated disorder, disease, or condition.本文提供適用於調節COPD內調控激酶(regulated-in-COPD kinase)活性之3,5-二胺基吡唑,例如式IA化合物,及其醫藥組合物。本文亦提供其用於治療、預防或改善RC激酶介導之病症、疾病或病狀之一或多種症狀之方法。